1.1: 80 percent / m-CPBA / toluene / 24 h / 20 °C 2.1: 63 percent / H2SO4; H2O / dioxane / 2.5 h / Heating 3.1: 100 percent / DMAP / pyridine; CH2Cl2 / 2 h 4.1: 67 percent / NaIO4 / RuCl3 / ethyl acetate; acetonitrile; H2O / 3 h / 20 °C 5.1: 100 percent / methanol / 0.25 h 6.1: LiBH4 / tetrahydrofuran / 8 h / 20 °C 6.2: DMAP; Ac2O / pyridine; CH2Cl2 / 2 h 6.3: aq. HCl / 18 h / Heating View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / NaOAc / Pd₂(dba)3*dba / acetonitrile / 0.33 h<br />2: HCO₂H / ethyl acetate / 0.67 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 55 percent / 2,6-di-tert-butyl-4-methylpyridine / Pd(OAc)2 / ethanol / 55 &deg;C<br />2: 74 percent / HF-pyr / tetrahydrofuran / 72 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>2: 55 percent / 2,6-di-tert-butyl-4-methylpyridine / Pd(OAc)2 / ethanol / 55 &deg;C<br />3: 74 percent / HF-pyr / tetrahydrofuran / 72 h / 20 &deg;C<br /> <br /> &nbsp;