N-(3-氯-4-氟苯甲酰基)-哌啶-4-酮合成路线 （共 5 条）
参考文献
Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660
反应条件
1: TEA / CHCl3 / 17 h / Ambient temperature 2: 80 percent aq. formic acid, CuSO4 / 16 h / 80 °C View Scheme
参考文献
Ribet; Pena; Maurel; Belin; Tillard; Vacher; Bonnaud; Colpaert
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2005 , vol. 62, # 1-3 p. 353 - 363
反应条件
1: dimethylsulfoxide / 3.5 h / 60 °C 2: 50 percent / HF*pyridine / CH2Cl2 / a) -10 deg C, 15 min, b) RT, 16 h View Scheme
参考文献
Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660
反应条件
1: dimethylsulfoxide / 3.5 h / 60 °C 2: 50 percent / HF*pyridine / CH2Cl2 / a) -10 deg C, 15 min, b) RT, 16 h 3: 83 percent / pyridine / Ambient temperature 4: 87 percent / dimethylformamide / 7 h / 150 °C 5: 87 percent / ethanolamine / 2 h / 60 °C View Scheme
参考文献
Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660
反应条件
1: dimethylsulfoxide / 3.5 h / 60 °C 2: 50 percent / HF*pyridine / CH2Cl2 / a) -10 deg C, 15 min, b) RT, 16 h 3: 83 percent / pyridine / Ambient temperature 4: 87 percent / dimethylformamide / 7 h / 150 °C 5: 87 percent / ethanolamine / 2 h / 60 °C 6: toluene / 2 h / Heating 7: KBH4 / methanol / 18 h / Ambient temperature View Scheme
参考文献
Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660
