4-溴-2,3-二甲基苯胺合成路线 （共 10 条）
反应条件
Oxonereg;; copper(ll) bromide in acetonitrile T=20°C; 3 h; regioselective reaction;
参考文献
Li, Xin-Le; Wu, Wei; Fan, Xin-Heng; Yang, Lian-Ming
RSC Advances, 2013 , vol. 3, # 30 p. 12091 - 12095
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Amaresh, Ramiya R.; Lakshmikantham; Baldwin, Jeffrey W.; Cava, Michael P.; Metzger, Robert M.; Rogers, Robin D.
Journal of Organic Chemistry, 2002 , vol. 67, # 8 p. 2453 - 2458
反应条件
1: NBS / CCl4 2: aq. HCl View Scheme
参考文献
Die Pharmazie, , vol. 24, # 2 p. 87 - 94
反应条件
potassium hydroxide; palladium on activated charcoal; hydrazine
参考文献
Chemische Berichte, , vol. 62, p. 2618
反应条件
hydrogen bromide; sodium nitrite anschliessend Behandeln mit Natriumhypophosphit und wss. Bromwasserstoffsaeure;
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 1418,1420
反应条件
1: 1.) 48percent aq. HBr, aq. NaNO2, 2.) 48percent aq. HBr, CuBr / 2.) reflux, 30 min 2: 57 percent / dimethylformamide / 4 h / Heating View Scheme
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 1418,1420
反应条件
1: With potassium acetate; acetic anhydride; 18-crown-6 ether in hexane; chloroform; ethyl acetate T=20 - 75°C; 16 h; Cooling with ice; 2: With hydrogenchloride in methanol; chloroform T=50°C; 2 h;
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
Location in patent: Page/Page column 25 ;
反应条件
1.1: chloroform / 20 °C / Cooling with ice 1.2: 0.17 h / 20 °C 1.3: 16 h / 75 °C 2.1: hydrogenchloride; water / methanol / 2 h / 50 °C View Scheme
参考文献
GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung
Patent: WO2011/72488 A1, 2011 ;
WO 2011/072488 A1
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 1418,1420
反应条件
hydrogen bromide; sodium nitrite
anschliessend Behandeln mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure;
参考文献
Lai, Yee-Hing; Yap, Angeline Hui-Tin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1373 - 1377
