4-异硫代氰酰基-N-甲基苯磺酰胺合成路线 (共 3 条)
反应条件
calcium carbonate in dichloromethane; water T=0 - 20°C; P=760.051 Torr; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BILOTTA, Joseph Anthony; CHEN, Zhi; CHIN, Elbert; DING, Qingjie; ERICKSON, Shawn David; GABRIEL, Stephen Deems; KLUMPP, Klaus; MA, Han; MERTZ, Eric; PLANCHER, Jean-Marc; WEIKERT, Robert James
Patent: WO2014/6066 A1, 2014 ;
Location in patent: Paragraph 0202 ;
反应条件
in 4-isothiocyanato0benzamide
参考文献
Agouron Pharmaceuticals Inc.
Patent: US6569878 B1, 2003 ;
US 6569878 B1
反应条件
1.1: sodium methylate / 0.25 h / 20 °C / 760.05 Torr / |Inert atmosphere 1.2: 1 h / 760.05 Torr / |Inert atmosphere 1.3: 20 °C / 760.05 Torr / |Inert atmosphere 2.1: hydrazine / ethanol / 3 h / 65 °C / 760.05 Torr / |Inert atmosphere View Scheme