2-(4-硝基亚苄基)丙二酸二乙酯合成路线 （共 14 条）
反应条件
1: concentrated sulfuric acid 2: fuming nitric acid / 0 °C View Scheme
参考文献
Stuart
Journal of the Chemical Society, 1885 , vol. 47, p. 155
反应条件
1: diethyl 2-[(4-nitrophenyl)methyl]propanedioate With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;
参考文献
Cao, Ying; Zhang, Song-Chen; Zhang, Min; Shen, Guang-Bin; Zhu, Xiao-Qing
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7154 - 7168
反应条件
1: diethyl malonate With sodium ethanolate in ethanol T=20°C; 0.333333 h; 2: diethyl 2-(4-nitrobenzylidene)propanedioate in ethanol T=20°C; 6 h; 3: With acetic acid in ethanol 0.0833333 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; DesJarlais, Renee Louise; Meegalla, Sanath K.; Wall, Mark; Wilson, Kenneth
Patent: US2007/249593 A1, 2007 ;
Location in patent: Page/Page column 24 ;
US 20070249593 A1
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C; Michael condensation; 2 h;
参考文献
Kaumanns, Oliver; Lucius, Roland; Mayr, Herbert
Chemistry - A European Journal, 2008 , vol. 14, # 31 p. 9675 - 9682
