反-4-(二乙胺基)肉桂醛合成路线 （共 6 条）
反应条件
1: cis-1-bromo-2-ethoxyethylene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.666667 h; 2: 4-[N,N-bis(ethyl)amino]benzaldehyde in tetrahydrofuran; pentane T=-78°C; 2 h;
参考文献
Lemercier, Gilles; Martineau, Cecile; Mulatier, Jean-Christophe; Wang, Irene; Stephan, Olivier; Baldeck, Patrice; Andraud, Chantal
New Journal of Chemistry, 2006 , vol. 30, # 11 p. 1606 - 1613
反应条件
Dess-Martin periodane in dichloromethane T=20°C;
参考文献
Journal of the American Chemical Society, , vol. 133, # 17 p. 6642 - 6649
反应条件
1: 41.67 g / NH4OAc / toluene; pyridine / 48 h / Heating 2: DIBAL / toluene / 0 deg C -> RT, 3 h 3: 18.1 g / 3N H2SO4 / H2O; methanol; toluene View Scheme
参考文献
Synthetic Communications, , vol. 18, # 14 p. 1641 - 1650
反应条件
hydrogenchloride in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Chao, Herbert S.-I.
Synthetic Communications, 1988 , vol. 18, # 14 p. 1641 - 1650
反应条件
nickel in formic acid; water T=80°C; 1.5 h; other reagent, solvent, reaction time; Product distribution;
参考文献
Chao, Herbert S.-I.
Synthetic Communications, 1988 , vol. 18, # 14 p. 1641 - 1650
反应条件
oxalic acid; lithium diisopropyl amide 1.) cyclohexane, 0 deg C, 10 min, 2.) cyclohexane-Et2O, -70 deg C -> RT, 3.) THF-H2O, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 18, # 14 p. 1641 - 1650
