2,2'-O-脱水-5-甲基尿嘧啶核苷合成路线 （共 43 条）
反应条件
1.1: 75 percent / B(OCH2CH2OCH3)3; NaHCO3 / 18 h / 130 °C / atmospheric pressure
2.1: pyridine
3.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
3.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
3.3: aq. NH3 / dioxane / 25 °C
4.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
pyridine; pyridin-2-yl hydrobromide
3 h; Heating;
参考文献
Rao, A. V. Rama; Gurjar, Mukund K.; Lalitha, Sista V. S.
Journal of the Chemical Society, Chemical Communications, 1994 , # 10 p. 1255 - 1256
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Vanheusden, Veerle; Munier-Lehmann, Helene; Pochet, Sylvie; Herdewijn, Piet; Van Calenbergh, Serge
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 19 p. 2695 - 2698
