4-羟基环己酮乙二醇缩醛合成路线 （共 42 条）
反应条件
silver(l) oxide
T=20°C; 288 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/107565 A1, 2007 ;
Location in patent: Page/Page column 60-61 ;
WO 2007/107565 A1
反应条件
1: silver(l) oxide / 96 h
2: toluene-4-sulfonic acid; water / tetrahydrofuran / 100 °C
View Scheme
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
反应条件
1: 93 percent / NaH / tetrahydrofuran / Heating
2: 75 percent / 2 M aq. H2SO4 / acetone / Heating
3: 98 percent / HCl / ethanol / Heating
4: 85 percent / diethyl ether / Ambient temperature
5: DBU / tetrahydrofuran / 4 h / -5 °C
6: diethyl ether / -78 °C
View Scheme
参考文献
Hwu; Leopold
Journal of the Chemical Society - Series Chemical Communications, 1984 , vol. NO. 11, p. 721 - 723
反应条件
1: 2.5 N aq. HCl / methanol / 48 h / Ambient temperature
2: 1.) Mg / 1.) THF, 2.) THF, reflux, 24 h
3: etheral HCl
View Scheme
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0°C; 5 h;
参考文献
CRYPTOPHARMA PTY LTD
Patent: WO2008/124878 A1, 2008 ;
Location in patent: Page/Page column 83 ;
反应条件
1: imidazole / dimethylformamide / 20 °C
2: 81 percent / NaI; CeCl3*7H2O / acetonitrile / 1 h / Heating
3: 95 percent / potassium hexamethyldisilazide / tetrahydrofuran; toluene / 4 h / -78 °C
View Scheme
参考文献
Carreno, M. Carmen; Urbano, Antonio; Di Vitta, Claudio
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8320 - 8330
反应条件
in methanol; water
48 h; Ambient temperature;
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
hydrogenchloride in methanol
48 h; Ambient temperature;
参考文献
Lednicer; Von Voigtlander; Emmert
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 341 - 346
反应条件
1: triethylamine / dichloromethane
2: hydrogenchloride / water; 1,4-dioxane
View Scheme
参考文献
Heugebaert, Thomas S.A.; Van Overtveldt, Melissa; De Blieck, Ann; Wuyts, Benjamin; Augustijns, Patrick; Ponce-Gamez, Eugenia; Rivera, Alicia; De Groote, Dominic; Lefebvre, Romain A.; Wouters, Patrick; Meert, Theo; Devulder, Jacques; Stevens, Christian V.
RSC Advances, 2014 , vol. 4, # 5 p. 2226 - 2234
反应条件
1: 1,4-dioxaspiro[4.5]-decan-8-ol With sodium hydride in tetrahydrofuran
T=0°C; 1.5 h;
2: benzyl bromide in tetrahydrofuran
T=0 - 20°C;
参考文献
Emory University
Patent: US2006/292073 A1, 2006 ;
Location in patent: Page/Page column 12 ;
