4-(Boc-氨基)环己醇合成路线 （共 19 条）
反应条件
in tetrahydrofuran; water
参考文献
US5574044 A1, ;
US 5574044 A
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=20°C; 1 h;
参考文献
INCYTE CORPORATION
Patent: WO2007/130898 A1, 2007 ;
Location in patent: Page/Page column 44 ;
WO 2007/130898 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-60°C; 1.25 h; 2: With triethylamine in dichloromethane T=-60 - 20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 71 ;
EP 1403255 A1
反应条件
molecular sieves in dichloromethane; ethyl acetate
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US5574044 A1, 1996 ;
US 5574044 A
反应条件
in ethyl acetate; Petroleum ether
参考文献
AGIOS PHARMACEUTICALS, INC; Lemieux, Rene M.; Popovici-Muller, Janeta; Travins, Jeremy; Cai, Zhenwei; Cui, Dawei; Zhou, Ding
Patent: US2013/190249 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
1: Petroleum ether; ethyl acetate
2: diethylamino-sulfur trifluoride; sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid / Petroleum ether; ethyl acetate; methanol; water
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / -5 - 20 °C / |Inert atmosphere
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
