1,3-二甲基-5-碘苯合成路线 （共 74 条）
反应条件
1: Pd2(dba)3; NaO-t-Bu / dioxane / 45 °C
2: 78 percent / Pd(OAc)2; PCy3*HBF4; K2CO3 / N,N-dimethyl-acetamide / 130 °C
View Scheme
参考文献
Campeau, Louis-Charles; Parisien, Mathieu; Jean, Annie; Fagnou, Keith
Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 581 - 590
反应条件
potassium phosphate; copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane in 1,4-dioxane; N-dodecane
T=110°C; 24 h;
参考文献
Klapars; Antilla; Huang; Buchwald
Journal of the American Chemical Society, 2001 , vol. 123, # 31 p. 7727 - 7729
反应条件
Pd(dba)2*o-C6H4-lt;P(cyclohex)2gt;-lt;C(Me)(-OCH2CH2O-)gt;; cesium fluoride in 1,4-dioxane
T=100 - 110°C;
参考文献
Wolf, Christian; Ekoue-Kovi, Kekeli
European Journal of Organic Chemistry, 2006 , # 8 p. 1917 - 1925
反应条件
C70H100N10O10; potassium tert-butylate
T=120°C; 24 h; Schlenk techniqueSealed tubeInert atmosphere;
参考文献
Zhao, Huaiqing; Shen, Jie; Guo, Juanjuan; Ye, Ruijuan; Zeng, Huaqiang
Chemical Communications, 2013 , vol. 49, # 23 p. 2323 - 2325
反应条件
sodium hydroxide; dihydrogen di-.mu.-chlorodichlorobis(di-tert-butylphosphinito-.kappa.P)dipalladate(2-)
T=135°C; 24 h;
参考文献
Lerebours, Rachel; Wolf, Christian
Synthesis, 2005 , # 14 art. no. M01405SS, p. 2287 - 2292
反应条件
K3PO4*3H2O in ethanol; water
T=60°C; Suzuki-Miyaura cross-coupling reaction; 0.25 h;
参考文献
Guan, Zhenhong; Hu, Jianglin; Gu, Yanlong; Zhang, Haojun; Li, Guangxing; Li, Tao
Green Chemistry, 2012 , vol. 14, # 7 p. 1964 - 1970
反应条件
potassium phosphate; palladium diacetate
T=20°C; 6 h;
参考文献
Zhou, Qing; Wei, Shaohua; Han, Wei
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1454 - 1460
反应条件
copper(l) iodide; sodium azide; L-proline; sodium hydroxide in dimethyl sulfoxide
T=60°C; 5 h;
参考文献
Zhu, Wei; Ma, Dawei
Chemical communications (Cambridge, England), 2004 , # 7 p. 888 - 889
反应条件
1: chlorine
2: aq. Na2CO3 / 20 °C
3: 91 percent / dimethylformamide / Heating
View Scheme
参考文献
Benjahad, Abdellah; Guillemont, Jerome; Andries, Koen; Nguyen, Chi Hung; Grierson, David S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4309 - 4312
反应条件
glycine-N',N'-dimethylamide hydrochloride; caesium carbonate; copper(l) iodide
T=110°C; Ullmann coupling reaction; 24 h;
参考文献
Zhang, Hui; Ma, Dawei; Cao, Weiguo
Synlett, 2007 , # 2 p. 243 - 246
