1,3-二甲基-5-碘苯合成路线 （共 74 条）
反应条件
FeCl3*6H2O; (+/-)-2,2'-diamino-6,6'-dimethylbiphenyl; sodium hydrogencarbonate in water; N,N-dimethyl-formamide
T=135°C; Mizoroki-Heck reaction; 24 h; Inert atmosphere;
参考文献
Wang, Xiu-Ren; Chen, Fan
Journal of Chemical Research, 2010 , vol. 34, # 12 p. 714 - 716
反应条件
copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine in n-butyronitrile
T=70°C; 24 h; Inert atmosphere;
参考文献
Maiti, Debabrata; Buchwald, Stephen L.
Journal of the American Chemical Society, 2009 , vol. 131, # 47 p. 17423 - 17429
反应条件
copper(l) iodide; silver fluoride; sodium t-butanolate; N-methyl-2-(methylamino)ethylamine in 1-methyl-pyrrolidin-2-one
T=20 - 90°C; 5.5 h; Inert atmosphere;
参考文献
Weng, Zhiqiang; Lee, Richmond; Jia, Weiguo; Yuan, Yaofeng; Wang, Wenfeng; Feng, Xue; Huang, Kuo-Wei
Organometallics, 2011 , vol. 30, # 11 p. 3229 - 3232
反应条件
in dimethylformamide [DMF]; perfluoromethyl iodide
参考文献
Merck and Co., Inc.
Patent: US4721791 A1, 1988 ;
反应条件
ZnF2; copper(I) bromide
T=150°C; 36 h; Sealed tubeUnder air;
参考文献
Luo, Fang; Pan, Changduo; Li, Liping; Chen, Fan; Cheng, Jiang
Chemical Communications, 2011 , vol. 47, # 18 p. 5304 - 5306
反应条件
copper(l) iodide in N,N-dimethyl-formamide
T=140°C; 36 h;
参考文献
Baskin, Jeremy M.; Wang, Zhaoyin
Organic Letters, 2002 , vol. 4, # 25 p. 4423 - 4425
反应条件
1: 1-methylpropyl iodide With zinc in tetrahydrofuran
T=20°C; Inert atmosphere;
2: 3,5-dimethylphenyl iodide With terpyridine; nickel dichloride in tetrahydrofuran
T=40°C; Negishi coupling reaction; 17 h; Inert atmosphere;
参考文献
Joshi-Pangu, Amruta; Ganesh, Madhu; Biscoe, Mark R.
Organic Letters, 2011 , vol. 13, # 5 p. 1218 - 1221
反应条件
potassium phosphate; copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane in 1,4-dioxane
T=110°C; 23 h;
参考文献
Klapars; Antilla; Huang; Buchwald
Journal of the American Chemical Society, 2001 , vol. 123, # 31 p. 7727 - 7729
反应条件
copper(l) iodide; (11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol; caesium carbonate
T=82°C; Ullmann coupling; 36 h;
参考文献
Naidu, Ajay B.; Jaseer; Sekar, Govindasamy
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 3675 - 3679
反应条件
potassium phosphate; copper(l) iodide; lithium amide in N,N-dimethyl-formamide
T=130°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Tlili, Anis; Monnier, Florian; Taillefer, Marc
Chemical Communications, 2012 , vol. 48, # 51 p. 6408 - 6410
