3,3-甲基哌嗪-2-酮合成路线 （共 10 条）
反应条件
potassium hydroxide in toluene Heating;
参考文献
Benjahad, Abdellah; Benhaddou, Rachida; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; et al.
Tetrahedron Letters, 1994 , vol. 35, # 51 p. 9545 - 9548
参考文献
Journal of the American Chemical Society, , vol. 62, p. 1202
参考文献
Rohm and Haas Co.
Patent: US2633467 , 1952 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=22 - 59°C; 5 h; 2: With sodium hydroxide in water T=23 - 25°C; 1.83333 h;
参考文献
H. LUNDBECK A/S
Patent: WO2006/86985 A1, 2006 ;
Location in patent: Page/Page column 14-15 ;
反应条件
potassium iodide in ethanol 24 h; Heating;
参考文献
Benjahad, Abdellah; Benhaddou, Rachida; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; et al.
Tetrahedron Letters, 1994 , vol. 35, # 51 p. 9545 - 9548
参考文献
Ruby; de Benneville
Journal of the American Chemical Society, 1953 , vol. 75, p. 3027
反应条件
triethylamine in DCM
T=20°C;
参考文献
LOCUS PHARMACEUTICALS, INC.
Patent: US2010/41642 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
1: 13 percent / sodium hydride / dimethylformamide / 0.17 h / 80 °C
2: 100 percent / NaAlH2(OCH2CH2OCH3)2 / toluene / 1 h / 100 °C
View Scheme
参考文献
Miyamoto, Teruyuki; Matsumoto, Jun-ichi; Chiba, Katsumi; Egawa, Hiroshi; Shibamori, Koh-ichiro; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1645 - 1656
