2-(2-乙氧基苯基)-5-甲基-7-丙基-3H-咪唑并[5,1-f][1,2,4]三嗪-4-酮合成路线 （共 18 条）
反应条件
potassium tert-butylate in tert-butyl alcohol T=160°C; 30 h;
参考文献
Heim-Riether, Alexander; Rotella, David Paul
Patent: US2006/264624 A1, 2006 ;
Location in patent: Page/Page column 6; 10 ;
反应条件
trichlorophosphate in toluene 2 h; Reflux;
参考文献
Olszewska, Teresa; Gajewska, Ewa P.; Milewska, Maria J.
Tetrahedron, 2013 , vol. 69, # 2 p. 474 - 480
反应条件
pyridine; sodium hydrogencarbonate; hydrazine hydrate; trichlorophosphate in tetrahydrofuran; ethanol; ethyl acetate; 1,2-dichloro-ethane
参考文献
Bayer Aktiengesellschaft
Patent: US6362178 B1, 2002 ;
反应条件
1.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C 1.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C 2.1: 52 percent / pyridine / 2 h / 60 °C 3.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 18 p. 7331 - 7337
反应条件
1: 52 percent / pyridine / 2 h / 60 °C 2: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 18 p. 7331 - 7337
反应条件
1.1: 53 percent / ammonium hydroxide / 24 h / 130 °C 2.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C 2.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C 3.1: 52 percent / pyridine / 2 h / 60 °C 4.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 18 p. 7331 - 7337
反应条件
1: in ethanol T=70°C; 4 h; 2: With trichlorophosphate in 1,2-dichloro-ethane 2 h; Heating / reflux;
参考文献
EP1174431 A2, ;
Page 42 ;
反应条件
1.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 14 h / |Reflux; |Inert atmosphere 2.1: ammonia / tetrahydrofuran / 20 °C 3.1: tertiary amine / dichloromethane / 0.08 h / |Cooling 3.2: 1.17 h / 0 - 20 °C 4.1: trichlorophosphate / toluene / 2 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 69, # 2 p. 474 - 480
反应条件
1.1: ammonia / tetrahydrofuran / 20 °C 2.1: tertiary amine / dichloromethane / 0.08 h / |Cooling 2.2: 1.17 h / 0 - 20 °C 3.1: trichlorophosphate / toluene / 2 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 69, # 2 p. 474 - 480
反应条件
1.1: tertiary amine / dichloromethane / 0.08 h / |Cooling 1.2: 1.17 h / 0 - 20 °C 2.1: trichlorophosphate / toluene / 2 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 69, # 2 p. 474 - 480
