1: With copper(l) chloride
T=85°C; 14.5 h; Cooling with iceInert atmosphere;
2: With ethanethioamide in methanol
T=45°C; 1 h; Cooling with iceInert atmosphere;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/156951 A2, 2009 ;
Location in patent: Page/Page column 46 ;
WO 2009/156951 A2