N-乙氧羰基邻苯二甲酰亚胺合成路线 （共 86 条）
反应条件
in water T=20°C; 3 h;
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
反应条件
1.1: tetrahydrofuran / 20 °C 1.2: MeOH; Et3N / tetrahydrofuran / 1 h 2.1: 747 mg / trichloroacetic acid / acetonitrile / 1 h View Scheme
参考文献
Dai, Qing; Deb, Shirshendu K.; Hougland, James L.; Piccirilli, Joseph A.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 705 - 713
反应条件
1: 99 percent / Et3N / tetrahydrofuran / 6 h / Ambient temperature 2: 62 percent / PCC, SiO2 / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Li, An-Hu; Moro, Stefano; Forsyth, Nancy; Melman, Neli; Ji, Xiao-Duo; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 706 - 721
反应条件
in 1,2-dichloro-ethane
2 h; Ambient temperature;
参考文献
Fry Jr.; Maienthal; Benson
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 5 p. 568 - 569
反应条件
triethylamine in dichloromethane
72 h; Ambient temperature;
参考文献
Holladay; Kopecka; Miller; Bednarz; Nikkel; Bianchi; Witte; Shiosaki; Chun Wel Lin; Asin; Nadzan
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 630 - 635
反应条件
sodium carbonate in water
6 h;
参考文献
Itoh; Kori; Inada; Nishikawa; Kawamatsu; Sugihara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 2078 - 2089
反应条件
1: 68 percent / Et3N / dimethylsulfoxide / 12 h / 4 - 20 °C
2: 55 percent / aq. NaIO4 / RuO2 / ethyl acetate; CH2Cl2 / 40 °C
View Scheme
参考文献
Varala, Ravi; Adapa, Srinivas R.
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 853 - 856
反应条件
1: 64 percent / ethanol / 6 h
2: 93 percent / pyridine hydrochloride / 0.17 h / 150 °C
3: 75 percent / H2 / 5 percent Pd/C / methanol; tetrahydrofuran / 760 Torr
View Scheme
参考文献
Hoffman; Wai; Thomas; Levin; O'Brien; Goldman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3784 - 3791
参考文献
Nutt, Ruth F.; Joullie, Madeleine M.
Journal of the American Chemical Society, 1982 , vol. 104, # 21 p. 5852 - 5853
反应条件
1: 100 percent / toluene / 1) 1h ambient temperature 2) 1h reflux
2: 12 percent / m-chloroperoxybenzoic acid / CH2Cl2 / Heating
3: 1) N-bromsuccinimide 2) 1,5-diazabicyclo<5.4.0>undec-5-en (DBU) / 1) dibenzoylperoxide, CCl4, 60 min reflux 2) THF, a) cooling with CO2 (s)/CCl4, b) ambient temperature (24h)
4: over silica gel
View Scheme
参考文献
Rastetter, William H.; Nummy, Larry J.
Journal of Organic Chemistry, 1980 , vol. 45, # 16 p. 3149 - 3155
