3-(三氟甲基)苯甲酰氯合成路线 （共 34 条）
反应条件
1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile 1 h; 2: 3-trifluoromethyl-benzoyl chloride in acetonitrile T=10 - 20°C; Cooling with ice;
参考文献
Bayer CropScience AG
Patent: US2012/65063 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
ammonium hydroxide T=20°C; 0.5 h;
参考文献
Kakuta, Hiroki; Zheng, Xiaoxia; Oda, Hiroyuki; Harada, Shun; Sugimoto, Yukio; Sasaki, Kenji; Tai, Akihiro
Journal of Medicinal Chemistry, 2008 , vol. 51, # 8 p. 2400 - 2411
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Panini, Piyush; Chopra, Deepak
CrystEngComm, 2012 , vol. 14, # 6 p. 1972 - 1989
参考文献
AstraZeneca AB
Patent: US6579872 B1, 2003 ;
US 6579872 B1
反应条件
in methanol; benzene Ambient temperature;
参考文献
Houlihan; Gogerty; Parrino; Ryan
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 765 - 768
反应条件
in acetonitrile T=25°C; Substitution; Kinetics;
参考文献
Kevill, Dennis N.; Wang, William F. K.
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 12 p. 2631 - 2637
反应条件
in tetrahydrofuran T=20°C;
参考文献
TARGEGEN, INC.
Patent: WO2008/8234 A1, 2008 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: FeCl3 / 3 h / 20 - 40 °C 2: Zn, NaOH / aq. ethanol / 2 h / Heating View Scheme
参考文献
Lichtenberger,J.; Weiss,F.
Bulletin de la Societe Chimique de France, 1962 , p. 587 - 593
反应条件
BTISA in dichloromethane Friedel Crafts acylation; 16 h; RefluxInert atmosphere;
参考文献
Posternak, Anna G.; Garlyauskayte, Romute Yu.; Yagupolskii, Lev M.
Tetrahedron Letters, 2009 , vol. 50, # 4 p. 446 - 447
反应条件
triethylamine in dichloromethane T=0 - 20°C; 0.5 h;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2006/13095 A2, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/013095 A2
