4-氟-4-羟基-联苯-3-羧酸合成路线 （共 9 条）
反应条件
acetic anhydride in pyridine
参考文献
Merck and Co., Inc.
Patent: US4044049 A1, 1977 ;
反应条件
sodium carbonate; palladium dichloride in water
T=20°C; 3 h;
参考文献
Bumagin, N. A.; Bykov, V. V.; Beletskaya, I. P.
Doklady Chemistry, 1990 , vol. 315, # 4-6 p. 354 - 357
Dokl. Akad. Nauk SSSR Ser. Khim., 1990 , vol. 315, # 5 p. 1133 - 1136
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran
-78 deg C, 10 min, 20 deg C, 3 h;
参考文献
Bumagin, Nikolai A.; Luzikova, Elena V.
Journal of Organometallic Chemistry, 1997 , vol. 532, # 1-2 p. 271 - 273
反应条件
1: 3-carboxy-4-hydroxybenzenediazonium tetrafluoroborate With palladium diacetate in methanol
Suzuki-Miyaura reaction; 0.166667 h; Inert atmosphere;
2: potassium (4-fluorophenyl)trifluoroborate in methanol
T=20°C; Suzuki-Miyaura reaction; 12 h; Inert atmosphere;
参考文献
Schmidt, Bernd; Hoelter, Frank
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4914 - 4920
反应条件
1: hexane; methanol / 11 h / 20 °C
2: 4.93 g / K2CO3 / dimethylformamide / 24 h / 20 °C
3: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 15 h / 60 °C
4: BBr3 / CH2Cl2 / 4 h / 20 °C
5: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
1: 4.93 g / K2CO3 / dimethylformamide / 24 h / 20 °C
2: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 15 h / 60 °C
3: BBr3 / CH2Cl2 / 4 h / 20 °C
4: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 15 h / 60 °C
2: BBr3 / CH2Cl2 / 4 h / 20 °C
3: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
1: BBr3 / CH2Cl2 / 4 h / 20 °C
2: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
cationic amphiphilic cyclodextrin (SC6CDNH2) in phosphate buffer
Flash photolysis; Kinetics; Further Variations:var. times;
参考文献
Sortino, Salvatore; Petralia, Salvatore; Darcy, Raphael; Donohue, Ruth; Mazzaglia, Antonino
New Journal of Chemistry, 2003 , vol. 27, # 3 p. 602 - 608
