1: 92 percent / aq. HCl / 4 h / Heating 2: 90 percent / BSA; TMS triflate / acetonitrile / 3.5 h / -45 - 20 °C View Scheme

hydrogenchloride 4 h; Heating;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: Et₃SiH; TFA / CH₂Cl₂ / 12 h / 20 &deg;C<br />1.2: 91 percent / H₂ / PtO₂ / ethanol / 0.5 h / 750.06 Torr<br />2.1: i-PrMgCl*LiCl / tetrahydrofuran / 5 h / 20 &deg;C<br />2.2: 87 percent / tetrahydrofuran / 20 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 93 percent / tetrahydrofuran / -78 &deg;C<br />2: 95 percent / NaOMe / 4 h / Heating<br /> <br /> &nbsp;