2-溴-4-羟基 苯甲醛合成路线 （共 10 条）
反应条件
1: With potassium hydroxide in chloroform; water T=70 - 75°C; 2: With hydrogenchloride in chloroform; water T=20°C;
参考文献
ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; DING, Charles; PLATTNER, Jacob; ALLEY, Michael, Richard Kevin; ZHANG, Yong-Kang; ZHANG, Yanchen
Patent: WO2011/37731 A1, 2011 ;
Location in patent: Page/Page column 111-112 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; dichloromethane; toluene T=0°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; dichloromethane; water; toluene T=40°C; 0.5 h;
参考文献
WO2012/168710 A1, ;
Page/Page column 45 ;
WO 2012/168710 A1
反应条件
1: With n-butyllithium in diethyl ether; pentane T=-78 - 20°C; 24 h; Inert atmosphere; 2: With carbon tetrabromide in diethyl ether; pentane T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether; pentane T=20°C; 2 h;
参考文献
Calter, Michael A.; Li, Na
Organic Letters, 2011 , vol. 13, # 14 p. 3686 - 3689
反应条件
sodium hydroxide in water T=70 - 75°C;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 4 p. 734 - 740
反应条件
1: 1-bromo-3-hydroxy-benzene With potassium hydroxide T=70 - 75°C; 2: chloroform in ethanol T=75°C; 3 h;
参考文献
Anson, Christopher E.; Creaser, Colin S.; Malkov, Andrej V.; Mojovic, Ljubica; Stephenson, G. Richard
Journal of Organometallic Chemistry, 2003 , vol. 668, # 1-2 p. 101 - 122
反应条件
1.1: toluene / 3 h / Reflux 2.1: n-butyllithium / diethyl ether; pentane / 24 h / -78 - 20 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 2.3: 2 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 13, # 14 p. 3686 - 3689
反应条件
1.1: anhydrous potassium trimethylsilanolate / N,N-dimethyl-formamide / 1 h / 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene; tetrahydrofuran / 1 h / 0 °C 2.2: 0.5 h / 40 °C View Scheme
参考文献
WO2012/168710 A1, ;
WO 2012/168710 A1
反应条件
hydrogenchloride; aluminium trichloride; benzene zuletzt bei 40grad;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 357, p. 373
反应条件
sodium hydroxide Mengenverhaeltnis zwischen den Produkten;
参考文献
Journal of the Chemical Society, , p. 469,470
反应条件
sodium hydroxide Mengenverhaeltnis zwischen den Produkten;
参考文献
Journal of the Chemical Society, , p. 469,470
