4-氯-6-碘噻吩并[3,2-D]嘧啶合成路线 （共 2 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1.33333 h; 2: With iodine in tetrahydrofuran T=-78 - 20°C; 2.33333 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/51304 A2, 2005 ;
Location in patent: Page/Page column 71 ;
WO 2005/051304 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; cesium fluoride in 1,4-dioxane; water
3 h; Reflux;
参考文献
Ni, Yike; Gopalsamy, Ariamala; Cole, Derek; Hu, Yonghan; Denny, Rajiah; Ipek, Manus; Liu, Julie; Lee, Julie; Hall, J. Perry; Luong, Michael; Telliez, Jean-Baptiste; Lin, Lih-Ling
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5952 - 5956
