6-溴-4-氯噻吩并[3,2-d]嘧啶合成路线 （共 5 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.333333 h; 2: With 1,2-dibromo-1,1,2,2-tetrafluoroethane in tetrahydrofuran T=-78 - 20°C; 2.33333 h;
参考文献
Yang, Beom-Seok; Kim, Yong-Zu; Park, Tae-Kyo; Woo, Sung-Ho; Lee, Hyang-Sook; Kim, Sun-Young; Cho, Jong-Un; Lee, Hong-Bum
Patent: US2013/72482 A1, 2013 ;
Location in patent: Paragraph 0211; 0218; 0219 ;
参考文献
Pfizer Inc.
Patent: US6492383 B1, 2002 ;
反应条件
1: CH3COONH4 / Heating 2: HCOONH4; HCONH2 / 140 °C 3: oxalyl chloride / dimethylformamide 4: BuLi; BrF2CCF2Br View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
反应条件
1: oxalyl chloride / dimethylformamide 2: BuLi; BrF2CCF2Br View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
反应条件
1: HCOONH4; HCONH2 / 140 °C 2: oxalyl chloride / dimethylformamide 3: BuLi; BrF2CCF2Br View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
