7-氯-2-(1-甲基-1H-咪唑-5-基)噻吩并[3,2-b]吡啶合成路线 （共 6 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene Heating / reflux;
参考文献
Methylgene, Inc.
Patent: US2007/4675 A1, 2007 ;
Location in patent: Page/Page column 63 ;
US 20070004675 A1
反应条件
hydrogenchloride in methanol
参考文献
Pfizer Inc.
Patent: US6492383 B1, 2002 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; Stille Cross Coupling; 40 h; Inert atmosphereLarge scale;
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -70 °C / |Inert atmosphere; |Large scale 1.2: 19.3 h / -70 - 20 °C / |Inert atmosphere; |Large scale 2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 40 h / 95 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
反应条件
1.1: diphenylether / 245 °C 2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane 3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -70 °C / |Inert atmosphere; |Large scale 3.2: 19.3 h / -70 - 20 °C / |Inert atmosphere; |Large scale 4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 40 h / 95 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane 2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -70 °C / |Inert atmosphere; |Large scale 2.2: 19.3 h / -70 - 20 °C / |Inert atmosphere; |Large scale 3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 40 h / 95 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Ragan; Raggon; Hill; Jones; McDermott; Munchhof; Marx; Casavant; Cooper; Doty; Lu
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 676 - 683
