hydrogenchloride; water T=150°C; 24 h;

hydrogenchloride T=20°C; 1 h;

1.1: methanol / 6 h / 0 - 20 °C 2.1: ozone; triphenylphosphine / methanol; dichloromethane / 6 h / -78 - 20 °C 3.1: anhydrous cyanoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere 3.2: 45004.5 Torr / Inert atmosphere 4.1: hydrogenchloride / water / 2.5 h / Reflux View Scheme

1.1: ozone; triphenylphosphine / methanol; dichloromethane / 6 h / -78 - 20 °C 2.1: anhydrous cyanoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere 2.2: 45004.5 Torr / Inert atmosphere 3.1: hydrogenchloride / water / 2.5 h / Reflux View Scheme

1.1: anhydrous cyanoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere 1.2: 45004.5 Torr / Inert atmosphere 2.1: hydrogenchloride / water / 2.5 h / Reflux View Scheme

hydrogenchloride in water 2.5 h; Reflux;

1: 5 Rh/C; hydrogen / methanol / 6 h / 20 °C / 45004.5 Torr 2: hydrogenchloride / water / 2.5 h / Reflux View Scheme

hydrogenchloride