1-甲基-3-[(E)-2-硝基乙烯基]苯合成路线 （共 8 条）
反应条件
sodium hydroxide in ethanol T=0°C; 2 h;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 1028 ;
反应条件
tetrafluoroboric acid; iodine; copper(II) oxide; sodium nitrite in acetonitrile T=20°C; Nitration; 7 h;
参考文献
Campos, Pedro J.; Garcia, Barbara; Rodriguez, Miguel A.
Tetrahedron Letters, 2000 , vol. 41, # 6 p. 979 - 982
反应条件
palladium (II) trifluoroacetate; silver(I) acetate in ethylene glycol dimethyl ether; dimethyl sulfoxide T=100°C; 24 h; GloveboxSchlenk techniqueInert atmosphere; Overall yield = 52 percent; regioselective reaction;
参考文献
Zhang, Min; Hu, Peng; Zhou, Jun; Wu, Ge; Huang, Shijun; Su, Weiping
Organic Letters, 2013 , vol. 15, # 7 p. 1718 - 1721
参考文献
Armarego,W.L.F.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 986 - 990
反应条件
1.1: chloro-trimethyl-silane; lithium borohydride / tetrahydrofuran 2.1: sodium carbonate / chloroform / 0 °C 3.1: trichlorophosphate; phosphorous pentoxide / 1 h / 110 °C 3.2: Cooling with ice View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 35 percent / LiAlH4 / tetrahydrofuran
2: 40 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 35 percent / LiAlH4 / tetrahydrofuran
2: 40 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
3: 58 percent / dimethylformamide / 25 h / 100 °C
4: 71 percent / polyphosphoric acid / 2 h / 145 °C
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
