(5R)-5-[(1,1-二甲基乙基)二甲基硅烷氧基]-2-环己烯-1-酮合成路线 （共 4 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 1.5 h; optical yield given as percent ee;
参考文献
Bolze, Patrick; Dickmeiss, Gustav; Jorgensen, Karl Anker
Organic Letters, 2008 , vol. 10, # 17 p. 3753 - 3756
反应条件
1: 1.) CuI, 2.) N,N'-(dimethylpropylene)urea, (EtO)3P / 1.) THF, -35 deg C, 15 min, 2.) THF, from -35 deg C to RT 2: Ti(Oi-Pr)4, i-PrMgCl / diethyl ether / a) -45 to -40 deg C, 1 h, b) from -40 deg C to RT, 90 min, c) RT, 2 h 3: FeCl3, pyridine / dimethylformamide / 0.5 h / Ambient temperature 4: NaOAc / methanol / 1 h / Ambient temperature View Scheme
参考文献
Hareau, Georges P.-J.; Koiwa, Masakazu; Hikichi, Shinichi; Sato, Fumie
Journal of the American Chemical Society, 1999 , vol. 121, # 15 p. 3640 - 3650
反应条件
1: Ti(Oi-Pr)4, i-PrMgCl / diethyl ether / a) -45 to -40 deg C, 1 h, b) from -40 deg C to RT, 90 min, c) RT, 2 h 2: FeCl3, pyridine / dimethylformamide / 0.5 h / Ambient temperature 3: NaOAc / methanol / 1 h / Ambient temperature View Scheme
参考文献
Hareau, Georges P.-J.; Koiwa, Masakazu; Hikichi, Shinichi; Sato, Fumie
Journal of the American Chemical Society, 1999 , vol. 121, # 15 p. 3640 - 3650
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 1 h; Title compound not separated from byproducts.;
参考文献
Honda; Endo
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 22 p. 2915 - 2919
