1-(1H-吲哚-3-基)-1-丙酮合成路线 （共 10 条）
参考文献
Oddo; Sessa
Gazzetta Chimica Italiana, 1911 , vol. 41, p. I 237
反应条件
diethylaluminium chloride in dichloromethane
T=0°C; Acylation; 2 h;
参考文献
Okauchi; Itonaga; Minami; Owa; Kitoh; Yoshino
Organic letters, 2000 , vol. 2, # 10 p. 1485 - 1487
反应条件
1: indole With diethylaluminium chloride in hexane; dichloromethane
T=-78 - -10°C; 0.25 h;
2: propionic acid anhydride in hexane; dichloromethane
T=-10 - 20°C; Friedel-Crafts reaction; 2 h;
参考文献
Wynne, James H.; Lloyd, Christopher T.; Jensen, Samuel D.; Boson, Sean; Stalick, Wayne M.
Synthesis, 2004 , # 14 p. 2277 - 2282
反应条件
1: 1.) AlCl3 / 1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h
2: 87 percent / K2CO3 / methanol; H2O / 2 h / Heating
View Scheme
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane / 1 h / 20 °C
2: AlCl3, aluminium chloride / dichloromethane / 2 h / 20 °C
3: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Reflux
View Scheme
参考文献
Xu, Hui; Bin Yang, Wen; Wang, Qin
Chemical Biology and Drug Design, 2011 , vol. 78, # 5 p. 864 - 868
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 2 h / 20 °C
2: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Reflux
View Scheme
参考文献
Xu, Hui; Bin Yang, Wen; Wang, Qin
Chemical Biology and Drug Design, 2011 , vol. 78, # 5 p. 864 - 868
参考文献
Upjohn Co.
Patent: GB869775 , 1959 ;
Full Text Show Details
Anthony
Journal of Organic Chemistry, 1960 , vol. 25, p. 2049,2050
参考文献
Oddo; Sessa
Gazzetta Chimica Italiana, 1911 , vol. 41, p. I 237
参考文献
Oddo; Sessa
Gazzetta Chimica Italiana, 1911 , vol. 41, p. I 237
反应条件
Yield given. Multistep reaction;
参考文献
Eyley, Stephen C.; Giles, Robert G.; Heaney, Harry
Tetrahedron Letters, 1985 , vol. 26, # 38 p. 4649 - 4652
