(S)-1-[3,5-二(三氟甲基)苯基]乙醇合成路线 （共 15 条）
反应条件
potassium formiate; Ru(OTf)[(S,S)-iso-BuSO2dpen](p-cymene) in methanol T=50°C; 24 h; Inert atmosphere;
参考文献
US2011/282077 A1, ;
Page/Page column 8 ;
反应条件
dimethylsulfide borane complex; chiral oxazaborolidine in dichloromethane; toluene T=-20°C; Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 5, # 23 p. 4249 - 4251
反应条件
3 A molecular sieve; oxygen; (-)-sparteine; Pd((-)-sparteine)2Cl2 in tert-butyl alcohol T=65°C; 20 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 68, # 11 p. 4600 - 4603
反应条件
Candida antartica lipase B in various solvent(s) T=40°C; P=67505.4 Torr; 2 h;
参考文献
Chemistry Letters, , vol. 34, # 8 p. 1102 - 1103
反应条件
1: sec-alkylsulfatase Pisa1 / dimethyl sulfoxide / 72 h / 30 °C / pH 8.2 / aq. buffer; Enzymatic reaction 2: toluene-4-sulfonic acid / 1,4-dioxane; tert-butyl methyl ether; water / 2 h / 40 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1737 - 1742
反应条件
Ti(3,3'-(MeO)2-BIPOLato)((R)-TADDOLato) in toluene T=-78 - -35°C; 12 h;
参考文献
Synlett, , # 12 p. 1889 - 1892
反应条件
toluene-4-sulfonic acid in 1,4-dioxane; tert-butyl methyl ether; water T=40°C; 2 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1737 - 1742
反应条件
sec-alkylsulfatase Pisa1 in dimethyl sulfoxide T=30°C; pH=8.2; 72 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1737 - 1742
反应条件
2,6-dimethylpyridine; lipase CAL-B in toluene T=40°C; 68 h;
参考文献
Synthetic Communications, , vol. 37, # 19 p. 3439 - 3446
反应条件
1: triethylamine/sulphur trioxide complex; sodium hydride / paraffin oil 2: sec-alkylsulfatase Pisa1 / dimethyl sulfoxide / 72 h / 30 °C / pH 8.2 / aq. buffer; Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1737 - 1742
