(2S)-氨基-n-[(1r,2r)-2-羟基-1-甲基-2-苯基乙基]-n-甲基-4-戊酰胺合成路线 （共 5 条）
反应条件
1: (R,R)-(-)-pseudoephedrine glycinamide hydrate With lithium chloride; lithium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.666667 h; 2: allyl bromide in tetrahydrofuran T=0°C; 1 h;
参考文献
Ryan, Shannon J.; Zhang, Yongda; Kennan, Alan J.
Organic Letters, 2005 , vol. 7, # 21 p. 4765 - 4767
反应条件
1.1: LiCl; LiHMDS / tetrahydrofuran 1.2: tetrahydrofuran View Scheme
参考文献
Myers, Andrew G.; Schnider, Patrick; Kwon, Soojin; Kung, Daniel W.
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3322 - 3327
反应条件
lithium chloride; lithium hexamethyldisilazane 1.) THF, 0 deg C, 20 min, 2.) 0 deg C, 1 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Myers, Andrew G.; Schnider, Patrick; Kwon, Soojin; Kung, Daniel W.
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3322 - 3327
反应条件
1: aq. NaOH / 2 h / Heating 2: 4.73 g / NaHCO3 / dioxane; H2O / 3 h / 0 - 20 °C View Scheme
参考文献
Ryan, Shannon J.; Zhang, Yongda; Kennan, Alan J.
Organic Letters, 2005 , vol. 7, # 21 p. 4765 - 4767
反应条件
sodium hydroxide 2 h; Heating;
参考文献
Ryan, Shannon J.; Zhang, Yongda; Kennan, Alan J.
Organic Letters, 2005 , vol. 7, # 21 p. 4765 - 4767
