1-BOC-3-溴-7-氮杂吲哚合成路线 （共 4 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 15 min, 2.) -78 deg C to r.t., 2 h;
参考文献
PROLYSIS LTD
Patent: WO2009/74812 A1, 2009 ;
Location in patent: Page/Page column 59 ;
WO 2009/074812 A1
反应条件
1: 3-bromo-1H-pyrrolo[2,3-b]pyridine With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: di-tert-butyl dicarbonate in N,N-dimethyl-formamide T=20°C;
参考文献
US2006/100218 A1, ;
Page/Page column 52 ;
US 20060100218 A1
反应条件
1: With potassium acetate in 1,4-dioxane 0.25 h; 2: With tri-cyclo-hexyl-phosphine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=100°C; 6.25 h;
参考文献
PROLYSIS LTD
Patent: WO2009/74812 A1, 2009 ;
Location in patent: Page/Page column 59; 60 ;
WO 2009/074812 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=65°C; Product distribution / selectivity;
参考文献
Ibrahim, Prabha N.; Bremer, Ryan; Gillette, Sam; Cho, Hanna; Nespi, Marika; Mamo, Shumeye; Zhang, Chao; Artis, Dean R.; Lee, Byunghun; Zuckerman, Rebecca
Patent: US2006/100218 A1, 2006 ;
Location in patent: Page/Page column 52 ;
US 20060100218 A1
