3-氟-N-甲氧基-N-甲基苯甲酰胺合成路线 （共 4 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 75 h;
参考文献
CYTOPIA PTY LTD
Patent: WO2004/52868 A1, 2004 ;
Location in patent: Page 29 ;
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0°C; Inert atmosphere; 2: 3-fluoro benzoic acid chloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
in tetrahydrofuran T=-78 - 20°C; 3.16667 h;
参考文献
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
Patent: US2010/331320 A1, 2010 ;
Location in patent: Page/Page column 53 ;
反应条件
1: meta-dibromobenzene With iodine; magnesium in diethyl ether T=20 - 30°C; Inert atmosphere; 2: 3-fluoro-N-methoxy-N-methylbenzamide in diethyl ether T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
