3-氯-1H-吡咯-2-羧酸甲酯合成路线 （共 5 条）
反应条件
1: With N-chloro-succinimide in tetrachloromethane T=85°C; 2: With sodium methylate in methanol 3 h; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
Location in patent: Page/Page column 143 ;
反应条件
methanol; sodium methylate 1.5 h; Reflux;
参考文献
Gruenenthal GmbH
Patent: US2010/222324 A1, 2010 ;
Location in patent: Page/Page column 48 ;
US 20100222324 A1
反应条件
in methanol T=0 - 20°C; 2.5 h;
参考文献
US2013/267521 A1, ;
Paragraph 1077 ;
反应条件
hydrogenchloride in dichloromethane 0.166667 h; Ambient temperature;
参考文献
Tehrani, Kourosch Abbaspour; Borremans, Didier; De Kimpe, Norbert
Tetrahedron, 1999 , vol. 55, # 13 p. 4133 - 4152
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C
2: “IBX”; sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 20 °C
View Scheme
参考文献
Fang, Zhanxiong; Liao, Pei-Chun; Yang, Yu-Liang; Yang, Feng-Ling; Chen, Yi-Lin; Lam, Yulin; Hua, Kuo-Feng; Wu, Shih-Hsiung
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7967 - 7978
