3-氯磺酰基-4-氟苯甲酸合成路线 （共 3 条）
反应条件
chlorosulfonic acid T=150°C; 24 h;
参考文献
Kudos Pharmaceuticals Ltd
Patent: US2004/2492 A1, 2004 ;
Location in patent: Page/Page column 48-49 ;
US 20040002492 A1
反应条件
1: aq. Na2SO3, aq. NaOH / 15 - 20 °C 2: K2CO3 / dimethylformamide / Ambient temperature View Scheme
参考文献
Baumgarth, Manfred; Beier, Norbert; Gericke, Rolf
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2017 - 2034
反应条件
1: aq. Na2SO3, aq. NaOH / 15 - 20 °C 2: aq. NaOH / methanol / 30 h / Heating View Scheme
参考文献
Baumgarth, Manfred; Beier, Norbert; Gericke, Rolf
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2017 - 2034
