(E)-3-(1,4-二噁螺[4.5]-7-癸基-7-基)丙烯酸合成路线 (共 4 条)
反应条件
sodium hydroxide in tetrahydrofuran; methanol; water 4 h;
参考文献
SCHERING CORPORATION
Patent: EP1036072 B1, 2004 ;
Location in patent: Page 100 ;
反应条件
CHIRAZYME L-9 in tert-butyl methyl ether T=35°C; 44 h; Enzymatic reactionResolution of racemate;
参考文献
SCHERING CORPORATION
Patent: WO2006/76565 A2, 2006 ;
Location in patent: Page/Page column 42-43 ;
反应条件
CHIRAZYME L-9 in tert-butyl methyl ether T=35°C; 21 h; Enzymatic reactionResolution of racemate;
参考文献
WO2006/76565 A2, ;
Page/Page column 40-42; 44-45 ;
反应条件
1: 71 percent / triethylamine / Pd(Ph3P)2Cl2 / dimethylformamide / 16 h / 75 °C 2: aq. NaOH / tetrahydrofuran; methanol / 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 1 p. 129 - 138