4-硝基-N-[2-(4-硝基苯氧基)乙基]苯乙胺合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=22°C; 60 h;
参考文献
WO2010/97248 A1, ;
Page/Page column 27-28 ;
WO 2010/097248 A1
反应条件
potassium carbonate in acetonitrile T=20°C;
参考文献
Liu, Hong; Ji, Ming; Luo, Xiaomin; Shen, Jianhua; Huang, Xiaoqin; Hua, Weiyi; Jiang, Hualiang; Chen, Kaixian
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 2953 - 2969
反应条件
1.1: NaOH; TBA / ethanol / 0.25 h / Heating 1.2: 46.8 percent / ethanol / 24 h / Heating 2.1: 81.5 percent / K2CO3 / acetonitrile / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2953 - 2969
反应条件
1: 76 g / conc. H2SO4; conc. HNO3 / 2 h 2: 99 percent / 47percent HBr / 6 h / Heating 3: 81.5 percent / K2CO3 / acetonitrile / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2953 - 2969
反应条件
1: 99 percent / 47percent HBr / 6 h / Heating 2: 81.5 percent / K2CO3 / acetonitrile / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2953 - 2969
反应条件
1: 2 h / 40 - 45 °C 2: 76 g / conc. H2SO4; conc. HNO3 / 2 h 3: 99 percent / 47percent HBr / 6 h / Heating 4: 81.5 percent / K2CO3 / acetonitrile / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2953 - 2969
