5-溴-2-甲基-2-戊烯合成路线 （共 93 条）
反应条件
in N,N-dimethyl-formamide 1) 80 deg C, 3 h; 2) RT, 3 h;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 32, # 1 p. 75 - 84
反应条件
in N-methyl-acetamide
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1633817/ 2: aq. HBr / 0.5 h / 10 - 15 °C 3: (i) Mg, Et2O, (ii) /BRN= 1702372/ 4: oxalic acid View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
反应条件
(i) Mg, Et2O, (ii) /BRN= 1861107/; Multistep reaction;
参考文献
Gutsche,C.D. et al.
Tetrahedron, 1968 , vol. 24, p. 859 - 876
反应条件
1: 65 percent / benzene / Heating 2: 1.) n-BuLi / 1.) ether, hexane, -5 deg C, 0.5 h, 2.) ether, RT, 0.5 h 3: 88.7 percent / TsOH / methanol / 0.5 h / Ambient temperature 4: 4 percent / PDC / CH2Cl2 / 1.5 h View Scheme
参考文献
Leal, Walter Soares; Kuwahara, Yasumasa; Suzuki, Takahisa
Agricultural and Biological Chemistry, 1989 , vol. 53, # 3 p. 875 - 878
参考文献
Shimizu, Nobuhiro; Mori, Naoki; Kuwahara, Yasumasa
Bioscience, Biotechnology and Biochemistry, 2001 , vol. 65, # 8 p. 1724 - 1728
反应条件
magnesium in diethyl ether
参考文献
Ohloff, Guenther; Giersch, Wolfgang; Decorzant, Rene; Buechi, George
Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1589 - 1597
反应条件
tert.-butyl lithium
1) ether, pentane, -23 deg C, 2 h; 2) ether, pentane, -78 deg C, 50 min; Multistep reaction. Yields of byproduct given;
参考文献
Coates, Robert M.; Jin, Alan Qingwu
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7475 - 7478
反应条件
1: (i) NaH, benzene, DMF, (ii) /BRN= 1735749/
2: (i) NaH, benzene, DMF, (ii) /BRN= 969135/
3: aq. KOH / ethane-1,2-diol / 2 h / 100 °C
View Scheme
参考文献
Mori; Matsui
Tetrahedron, 1969 , vol. 25, # 20 p. 5013 - 5018
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1633817/
2: aq. HBr / 0.5 h / 10 - 15 °C
3: (i) Mg, Et2O, (ii) /BRN= 1633817/, Et2O
4: aq. HBr / 0.75 h / Ambient temperature
View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
