5-溴-2-甲基-2-戊烯合成路线 （共 93 条）
反应条件
1.1: 92 percent / NaI / acetone / 20 h / 20 °C
2.1: t-BuLi / diethyl ether / 1 h / -78 °C
2.2: 52 percent / diethyl ether / 4 h / -78 °C
View Scheme
参考文献
Vickers, Troy D.; Keay, Brian A.
Synlett, 2003 , # 9 SPEC. ISS. p. 1349 - 1351
反应条件
hydrogenchloride; zinc(II) chloride in diethyl ether
T=20°C;
参考文献
Kraft, Philip; Bruneau, Audrey
European Journal of Organic Chemistry, 2007 , # 14 p. 2257 - 2267
反应条件
2: 79.8 percent / KOH / ethanol; H2O / 3 h / Heating
3: 80.4 percent / 88percent HCO2H, HClO4 / 0.5 h / Heating
View Scheme
参考文献
Hiranuma, Sayoko; Shibata, Misako; Hudlicky, Tomas
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5321 - 5326
反应条件
2: 1.) KOH 2.) LiAlH4
4: NaI
5: 86 percent / NaOEt / ethanol / Heating
View Scheme
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
1.1: 92 percent / NaI / acetone / 20 h / 20 °C
2.1: t-BuLi / diethyl ether / 1 h / -78 °C
2.2: 52 percent / diethyl ether / 4 h / -78 °C
3.1: aq. KOH / ethanol / 20 h / Heating
View Scheme
参考文献
Hiranuma, Sayoko; Shibata, Misako; Hudlicky, Tomas
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5321 - 5326
反应条件
Yield given. Multistep reaction;
参考文献
Hiranuma; Hudlicky
Tetrahedron Letters, 1982 , vol. 23, # 34 p. 3431 - 3434
反应条件
1: 92 percent / dimethylformamide / 1) 80 deg C, 3 h; 2) RT, 3 h
2: 36 percent / acetonitrile / Irradiation
View Scheme
参考文献
Machida, Minoru; Oda, Kazuaki; Kanaoka, Yuichi
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 75 - 84
反应条件
1: 1.) NaH / 1.) DMF, reflux, 12 h, 2.) DMF, reflux, 12 h
2: KOH / ethanol / 20 h / Heating
3: 93.9 percent / LiAlH4 / diethyl ether
4: 97.7 percent / pyridine / 72 h / Ambient temperature
View Scheme
参考文献
Ladika, Mladen; Sunko, Dionis E.
Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4544 - 4548
反应条件
(i) Mg, Et2O, (ii) /BRN= 606053/; Multistep reaction;
参考文献
Gutsche,C.D. et al.
Tetrahedron, 1968 , vol. 24, p. 859 - 876
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
