3,7-二甲基-6-辛烯酸甲酯合成路线 （共 22 条）
反应条件
1: 3.42 g / TsOH*Py / acetone; H2O / 2 h / Heating
2: 1.) butylithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h
3: 82 percent / H2 / Pt-black / ethanol / Ambient temperature
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Sakharova, N. I.; Tolstikov, G. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.1 p. 24 - 30
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 31 - 38
反应条件
1: 90 percent / copper(I) iodide / tetrahydrofuran; various solvent(s) / 4 h / -15 - -3 °C
View Scheme
参考文献
Fujisawa, Tamotsu; Sato, Toshio; Kawara, Tatsuo; Noda, Atsunari; Obinata,Toshiyuki
Tetrahedron Letters, 1980 , vol. 21, p. 2553 - 2554
反应条件
1: n-BuLi / tetrahydrofuran; hexane / 2 h / Ambient temperature
2: 2 h / 70 °C
3: 80.3 percent / triethylamine / 3 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Okamoto, Masao
Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5681 - 5684
反应条件
1: thionyl chloride / dimethylformamide / 1 h / 30 °C
2: 1 h / 20 °C
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Sakharova, N. I.; Tolstikov, G. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.1 p. 24 - 30
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 31 - 38
反应条件
1: sodium hydroxide / H2O; methanol / 2 h / Heating
2: quinoline / Heating
3: thionyl chloride / dimethylformamide / 1 h / 30 °C
4: 1 h / 20 °C
View Scheme
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Sakharova, N. I.; Tolstikov, G. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.1 p. 24 - 30
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 31 - 38
反应条件
T=20°C; 1 h; Yield given;
参考文献
Odinokov, V. N.; Kukovinets, O. S.; Sakharova, N. I.; Tolstikov, G. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.1 p. 24 - 30
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 31 - 38
参考文献
Cookson,R.C. et al.
Chemical Communications (London), 1968 , p. 180
反应条件
lithium diisopropyl amide
1.)THF, -78 deg C, 15 min.; 2.) HO, 25 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Snider, Barry B.; Phillips, Gary B.
Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 183 - 185
反应条件
1: 1.) i-Pr2NLi / 1.)THF, -78 deg C, 15 min.; 2.) HO, 25 deg C, 2.5 h
2: 1.) MeI, 2.) DBU / 1.) MeOH, 40 h; 2.) THF, 2 d
View Scheme
参考文献
Snider, Barry B.; Phillips, Gary B.
Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 183 - 185
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 15 min; 2.) THF, allowed to r.t. during 30 min; Yield given. Multistep reaction;
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Moriwaki, Hiroki; Harada, Suzumi; Okamoto, Masao
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4916 - 4926
