4-溴-2-羟基苯羧酸甲酯合成路线 （共 7 条）
反应条件
1: With sulfuric acid in methanol 24 h; Heating / reflux; 2: With sodium hydroxide
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1424336 A1, 2004 ;
Location in patent: Page 137 ;
反应条件
sulfuric acid T=80°C; 24 h;
参考文献
Innocenti, Paolo; Cheung, Kwai-Ming J.; Solanki, Savade; Mas-Droux, Corine; Rowan, Fiona; Yeoh, Sharon; Boxall, Kathy; Westlake, Maura; Pickard, Lisa; Hardy, Tara; Baxter, Joanne E.; Aherne, G. Wynne; Bayliss, Richard; Fry, Andrew M.; Hoelder, Swen
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3228 - 3241
反应条件
sodium hydroxide; hydroxylamine hydrochloride in 1,4-dioxane; water T=20°C; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/10995 A1, 2004 ;
Location in patent: Page/Page column 37 ;
WO 2004/010995 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation View Scheme
参考文献
Innocenti, Paolo; Cheung, Kwai-Ming J.; Solanki, Savade; Mas-Droux, Corine; Rowan, Fiona; Yeoh, Sharon; Boxall, Kathy; Westlake, Maura; Pickard, Lisa; Hardy, Tara; Baxter, Joanne E.; Aherne, G. Wynne; Bayliss, Richard; Fry, Andrew M.; Hoelder, Swen
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3228 - 3241
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Innocenti, Paolo; Cheung, Kwai-Ming J.; Solanki, Savade; Mas-Droux, Corine; Rowan, Fiona; Yeoh, Sharon; Boxall, Kathy; Westlake, Maura; Pickard, Lisa; Hardy, Tara; Baxter, Joanne E.; Aherne, G. Wynne; Bayliss, Richard; Fry, Andrew M.; Hoelder, Swen
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3228 - 3241
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) chloroform complex; caesium carbonate in 1,4-dioxane; water
参考文献
Petros, Andrew M.; Swann, Steven L.; Song, Danying; Swinger, Kerren; Park, Chang; Zhang, Haichao; Wendt, Michael D.; Kunzer, Aaron R.; Souers, Andrew J.; Sun, Chaohong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1484 - 1488
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) chloroform complex; caesium carbonate / 1,4-dioxane; water
2: sodium hydroxide / 1,4-dioxane
View Scheme
参考文献
Petros, Andrew M.; Swann, Steven L.; Song, Danying; Swinger, Kerren; Park, Chang; Zhang, Haichao; Wendt, Michael D.; Kunzer, Aaron R.; Souers, Andrew J.; Sun, Chaohong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1484 - 1488
