4-氧代-1,2,3,4-四氢萘-2-羧酸乙酯合成路线 （共 10 条）
反应条件
(i) KBH4, aq. MeOH, (ii) (heating), Pd-C, (iii) LiAlH4, Et2O; Multistep reaction;
参考文献
Julia,S. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 84 - 91
反应条件
1: diiodomethane With diethylzinc; trifluoroacetic acid in dichloromethane
0.5 h;
2: 2-carboethoxy-1-indanone in dichloromethane
T=20°C; 2 h;
参考文献
Xue, Song; Liu, Yong-Kang; Li, Le-Zhen; Guo, Qing-Xiang
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 8245 - 8247
反应条件
1: 3.32 g / H2 / palladium-black / dioxane / 16 h / Ambient temperature
2: (COCl)2 / 5 h / Ambient temperature
3: 3.96 mmol / AlCl3 / 1,2-dichloro-ethane / 16 h / Ambient temperature
View Scheme
参考文献
Suzuki; Tatsuoka; Ishihara; Ohno; Aisaka; Ogino; Kuroki; Satoh; Miyano; Sumoto
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 132 - 138
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol in tetrahydrofuran
Ambient temperature; Further byproducts given;
参考文献
Hasegawa, Eietsu; Kitazume, Takashi; Suzuki, Kimiko; Tosaka, Emi
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 4059 - 4062
反应条件
methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran
Ambient temperature; Further byproducts given;
参考文献
Hasegawa, Eietsu; Kitazume, Takashi; Suzuki, Kimiko; Tosaka, Emi
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 4059 - 4062
反应条件
1.1: sodium hydride; N,N,N',N',N'',N''-hexamethylphosphoric triamide / mineral oil; tetrahydrofuran / 1 h / |Inert atmosphere
1.2: 22 h / 75 °C / |Inert atmosphere
2.1: C10H25NSi / acetonitrile; water / 4 h / |Inert atmosphere; |Irradiation
View Scheme
参考文献
Hasegawa, Eietsu; Tosaka, Emi; Yoneoka, Akira; Tamura, Yukinobu; Takizawa, Shin-Ya; Tomura, Masaaki; Yamashita, Yoshiro
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 247 - 267
反应条件
1.1: sodium hydride; N,N,N',N',N'',N''-hexamethylphosphoric triamide / mineral oil; tetrahydrofuran / 1 h / |Inert atmosphere
1.2: 22 h / 75 °C / |Inert atmosphere
2.1: water-d2; 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole / N,N-dimethyl-formamide / 4 h / |Inert atmosphere; |Irradiation
View Scheme
参考文献
Hasegawa, Eietsu; Tosaka, Emi; Yoneoka, Akira; Tamura, Yukinobu; Takizawa, Shin-Ya; Tomura, Masaaki; Yamashita, Yoshiro
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 247 - 267
反应条件
1.1: sodium hydride
2.1: sodium hydride; N,N,N',N',N'',N''-hexamethylphosphoric triamide / mineral oil; tetrahydrofuran / 1 h / |Inert atmosphere
2.2: 22 h / 75 °C / |Inert atmosphere
3.1: C10H25NSi / acetonitrile; water / 4 h / |Inert atmosphere; |Irradiation
View Scheme
参考文献
Hasegawa, Eietsu; Tosaka, Emi; Yoneoka, Akira; Tamura, Yukinobu; Takizawa, Shin-Ya; Tomura, Masaaki; Yamashita, Yoshiro
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 247 - 267
反应条件
1.1: sodium hydride
2.1: sodium hydride; N,N,N',N',N'',N''-hexamethylphosphoric triamide / mineral oil; tetrahydrofuran / 1 h / |Inert atmosphere
2.2: 22 h / 75 °C / |Inert atmosphere
3.1: water-d2; 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole / N,N-dimethyl-formamide / 4 h / |Inert atmosphere; |Irradiation
View Scheme
参考文献
Hasegawa, Eietsu; Tosaka, Emi; Yoneoka, Akira; Tamura, Yukinobu; Takizawa, Shin-Ya; Tomura, Masaaki; Yamashita, Yoshiro
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 247 - 267
反应条件
1: LiAlH4 / diethyl ether
2: MnO2 / benzene
View Scheme
参考文献
Horii,Z. et al.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 887 - 892
