反应条件
Multi-step reaction with 8 steps 1.1: 86 percent / DMAP; DCC / CH2Cl2 / 0.33 h / 20 °C2.1: 61 percent / CsF; P(o-tol)3 / Pd2(dba)3*CHCl3 / acetonitrile / 4 h / 20 °C3.1: 78 percent / NaH / CH2Cl2 / 5 h / 20 °C4.1: DIBAL-H / CH2Cl2; toluene / 2 h / -78 °C4.2: 63 percent / aq. potassium sodium tartrate / CH2Cl2; methanol / -78 - 20 °C5.1: 95 percent / NaBH4 / methanol; tetrahydrofuran / 21 h / 20 °C6.1: 89 percent / molecular sieves 4 Angstroem; PCC / CH2Cl2 / 1.5 h / 0 °C7.1: mCPBA / CH2Cl2 / 1 h / 20 °C8.1: 54 mg / K2CO3 / methanol / 0.5 h / 20 °C
参考文献
Sato, Yoshihiro; Tamura, Takayuki; Kinbara, Atsushi; Mori, Miwako Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 647 - 661
