8,9,10-三羟基-7-(羟基甲基)-2-硫代-6-氧杂-1,3-二氮杂螺[4.5]癸烷-4-酮合成路线 （共 5 条）
反应条件
sodium methylate Ambient temperature;
参考文献
Somsak; Kovacs; Toth; Oesz; Szilagyi; Gyoergydeak; Dinya; Docsa; Gergely
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2843 - 2848
反应条件
methanol; sodium methylate Debenzoylation; Heating;
参考文献
Somsak, L.Aszlo; Nagy, Veronika
Tetrahedron Asymmetry, 2000 , vol. 11, # 8 p. 1719 - 1727
反应条件
1: 79 percent / S8 / nitromethane / 4 h / 80 °C 2: 78 percent / NaOMe; MeOH / 20 °C View Scheme
参考文献
Osz, Erzsebet; Somsak, Laszlo; Szilagyi, Laszlo; Kovacs, Laszlo; Docsa, Tibor; Toth, Bela; Gergely, Pal
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1385 - 1390
反应条件
1: 94 percent / HBr; AcOH / 3 h / 20 °C 2: 89 percent / Br2; BaCO3 / CCl4 / 2 h / Heating; irradiation 3: 79 percent / S / nitromethane / 7 h / 80 °C 4: 92 percent / NaOMe; MeOH / 2 h / Heating View Scheme
参考文献
Somsak, L.Aszlo; Nagy, Veronika; Docsa, Tibor; Toth, B.Ela; Gergely, P.Al
Tetrahedron Asymmetry, 2000 , vol. 11, # 2 p. 405 - 408
反应条件
1: 58 percent / nitromethane / 20 °C 2: 94 percent / HBr; acetic acid / 20 °C 3: 89 percent / Br2 / CHCl3 / Heating; irradiation 4: 79 percent / S8 / nitromethane / 80 °C 5: 92 percent / NaOMe; MeOH / Heating View Scheme
参考文献
Somsak, L.Aszlo; Nagy, Veronika; Docsa, Tibor; Toth, B.Ela; Gergely, P.Al
Tetrahedron Asymmetry, 2000 , vol. 11, # 2 p. 405 - 408
