1-(4,6-二乙基-2-嘧啶)哌嗪合成路线 （共 6 条）
反应条件
in dimethyl sulfoxide T=100°C; 16 h;
参考文献
Euro-Celtique, S.A.
Patent: WO2004/29044 A1, 2004 ;
Location in patent: Page 246 ;
反应条件
sodium methylate in methanol
参考文献
Lonza Ltd.
Patent: US5204465 A1, 1993 ;
反应条件
in ethanol 1.) ice bath, 2.) room temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
potassium carbonate in water T=50 - 65°C;
参考文献
Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju; Li, Zheng-Ming
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 9 p. 5515 - 5522
反应条件
1: 34.9 percent / 30percent aq. H2O2, HCOOH / 3 h / Ambient temperature 2: 65 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: 89.7 percent / aq. NaOH / 7 h / Ambient temperature 2: 34.9 percent / 30percent aq. H2O2, HCOOH / 3 h / Ambient temperature 3: 65 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
