1-[(4-甲氧基苯基)甲基]-1H-吡唑-5-胺盐酸盐合成路线 （共 2 条）
反应条件
1: acrylonitrile With hydrazine hydrate in tetrahydrofuran T=10°C; 2 h; 2: 4-methoxy-benzaldehyde in tetrahydrofuran 3: With sodium methylate in butan-1-ol T=20 - 120°C; 4 h;
参考文献
SANOFI; PLETTENBURG, Oliver; LOEHN, Matthias; MENDEZ-PEREZ, Maria; HACHTEL, Stephanie; PODESCHWA, Michael; KANNT, Aimo; IVASHCHENKO, Yuri; BJERGARDE, Kirsten
Patent: US2013/150340 A1, 2013 ;
Location in patent: Paragraph 0906; 0907; 0908 ;
反应条件
sodium hydroxide in tert-butyl methyl ether; water Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: EP1043998 B1, 2007 ;
Location in patent: Page/Page column 13 ;
