4-(3,4-二甲氧基苯甲酰基)吗啉合成路线 （共 6 条）
反应条件
potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether in toluene T=105°C; P=3000.3 Torr; 12 h;
参考文献
Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M.
ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410
反应条件
in dichloromethane T=0°C; 2 h;
参考文献
Greenhouse, Robert; Ramirez, Coral; Muchowski, Joseph M.
Journal of Organic Chemistry, 1985 , vol. 50, # 16 p. 2961 - 2965
反应条件
1: 3,4-dimethoxy-benzaldehyde With Br3COOEt; dibenzoyl peroxide in chlorobenzene T=110°C; 24 h; 2: morpholine With triethylamine in chlorobenzene T=20°C;
参考文献
Kang, Dong Ho; Joo, Tae Young; Chavasiri, Warinthorn; Jang, Doo Ok
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 285 - 287
反应条件
1: SOCl2 / CHCl3 / Heating 2: toluene / Ambient temperature View Scheme
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
tert.-butyl lithium 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
参考文献
Egis Gyogyszergyar
Patent: US5221673 A1, 1993 ;
