2-甲基-2-丙基7-苄基-9-氧代-3,7-二氮杂双环[3.3.1]壬烷-3-羧酸酯合成路线 （共 4 条）
反应条件
1: p-TsOH / dimethylformamide / 0.17 h / 100 °C 2: 302 mg / NaBH3CN / dimethylformamide / 2 h / 100 °C 3: H2 / 10percent Pd/C / ethanol / 12 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2013/50938 A1, 2013 ;
反应条件
1: With hydrazine hydrate in diethylene glycol T=60°C; 0.166667 h; 2: With potassium hydroxide in diethylene glycol T=160°C; 8 h;
参考文献
Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 623 - 626
反应条件
sodium cyanoborohydride; acetic acid in water; isopropyl alcohol; toluene
参考文献
AstraZeneca AB
Patent: US6291475 B1, 2001 ;
US 6291475 B1
反应条件
1.1: hydrazine hydrate / diethylene glycol / 0.17 h / 60 °C
1.2: 8 h / 160 °C
2.1: palladium 10 on activated carbon; hydrogen / ethanol / 4 h
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 623 - 626
