7-苄基-3,7-二氮杂双环[3.3.1]壬烷-3-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1: With hydrazine hydrate in diethylene glycol T=60°C; 0.166667 h; 2: With potassium hydroxide in diethylene glycol T=160°C; 8 h;
参考文献
Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 623 - 626
反应条件
in tetrahydrofuran T=20°C;
参考文献
AstraZeneca AB
Patent: EP1192154 B1, 2004 ;
Location in patent: Page 28 ;
反应条件
di-tert-butyl dicarbonate in tetrahydrofuran
参考文献
AstraZeneca AB
Patent: EP1192156 B1, 2004 ;
Location in patent: Page 24 ;
反应条件
sodium cyanoborohydride; acetic acid in water; isopropyl alcohol; toluene
参考文献
AstraZeneca AB
Patent: US6291475 B1, 2001 ;
US 6291475 B1
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol T=50°C; P=2844.39 Torr; 2 h;
参考文献
TARGACEPT, INC.
Patent: WO2009/111550 A1, 2009 ;
Location in patent: Page/Page column 38 ;
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 4 h
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 623 - 626
