3,7-二氮杂双环[3.3.1]-壬烷-3-羧酸叔丁酯合成路线 (共 3 条)
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol T=50°C; P=2844.39 Torr; 2 h;
参考文献
TARGACEPT, INC.
Patent: WO2009/111550 A1, 2009 ;
Location in patent: Page/Page column 38 ;
反应条件
1: p-TsOH / dimethylformamide / 0.17 h / 100 °C 2: 302 mg / NaBH3CN / dimethylformamide / 2 h / 100 °C 3: H2 / 10percent Pd/C / ethanol / 12 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2013/50938 A1, 2013 ;
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 2 h;
参考文献
Haridas; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 623 - 626