(S)-2-(氨甲基)-1-乙基吡咯烷合成路线 （共 20 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 8 h;
参考文献
Bishop; Mathis; Gerdes; Whitney; Eaton; Mailman
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1612 - 1624
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Hoegberg, Thomas; Raemsby, Sten; Stroem, Peter
Acta Chemica Scandinavica, 1989 , vol. 43, # 7 p. 660 - 664
反应条件
1: 79 percent / SOCl2 / CHCl3 / 4.5 h / 0 °C 2: 87 percent / NaN3, KI / dimethylformamide / 8 h 3: 75 percent / LiAlH4 / diethyl ether / 8 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1612 - 1624
反应条件
1: 87 percent / NaN3, KI / dimethylformamide / 8 h 2: 75 percent / LiAlH4 / diethyl ether / 8 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1612 - 1624
反应条件
1: 95 percent / K2CO3 / CH2Cl2 / 1.5 h 2: 79 percent / SOCl2 / CHCl3 / 4.5 h / 0 °C 3: 87 percent / NaN3, KI / dimethylformamide / 8 h 4: 75 percent / LiAlH4 / diethyl ether / 8 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1612 - 1624
反应条件
1: 88 percent / liquid NH3, molecular sieves 3A / methanol / 20 h / 50 °C 2: 69 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 43, # 7 p. 660 - 664
反应条件
1: 71 percent / K2CO3 / dimethylformamide / 3 h / Ambient temperature 2: 88 percent / liquid NH3, molecular sieves 3A / methanol / 20 h / 50 °C 3: 69 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 43, # 7 p. 660 - 664
反应条件
1: sodium hydrogencarbonate / N,N-dimethyl-formamide / |Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / |Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 49, # 77 p. 8686 - 8688
反应条件
in dichloromethane 4 h; Ambient temperature;
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
hydrogenchloride in water; butan-1-ol
参考文献
BERTOLINI, Giorgio; BOGOGNA, Luigi; PREGNOLATO, Massimo; TERRENI, Marco; VELARDI, Francesco
Patent: US2007/105201 A1, 2007 ;
