(S)-2-(氨甲基)-1-乙基吡咯烷合成路线 （共 20 条）
反应条件
in diethylene glycol T=80°C; 48 h;
参考文献
Botre, Claudio; Botre, Francesco; Jommi, Giancarlo; Signorini, Roberto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1814 - 1820
反应条件
hydrogenchloride in water; butan-1-ol
参考文献
BERTOLINI, Giorgio; BOGOGNA, Luigi; PREGNOLATO, Massimo; TERRENI, Marco; VELARDI, Francesco
Patent: US2007/105201 A1, 2007 ;
反应条件
in diethylene glycol T=80°C; 48 h;
参考文献
Botre, Claudio; Botre, Francesco; Jommi, Giancarlo; Signorini, Roberto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1814 - 1820
反应条件
in chloroform 2 h; Yield given;
参考文献
Kung; Kasliwal; Pan; Mach; Guo
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1039 - 1043
反应条件
1: 4,6-dichloro-2-iodo-3-methoxyphenol; (S)-(-)-1-ethyl-2-aminomethylpyrrolidine With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran sealed tubeInert atmosphere; 2: molybdenum hexacarbonate With pyridine in tetrahydrofuran T=70°C; 19 h; sealed tubeInert atmosphere;
参考文献
AARHUS UNIVERSITET; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; HERMANGE, Philippe; TAANING, Rolf Hejle; FRIIS, Stig Duering
Patent: WO2012/79583 A1, 2012 ;
Location in patent: Page/Page column 95; 96 ;
参考文献
Thurkauf, Andrew; Yuan, Jun; Chen, Xi; Wasley, Jan W. F.; Paneitz, Gregory; Meade, Robin; Woodruff, Kristine Harris; Huston, Kevin; Ross, Philip C.
Medicinal Chemistry Research, 1996 , vol. 6, # 2 p. 69 - 80
反应条件
dicyclohexyl-carbodiimide in chloroform
参考文献
Lu, S.; Adam, M. J.; Lu, J.; Ruth, T. J.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, p. S234 - S234
反应条件
in dichloromethane Ambient temperature; Yield given;
参考文献
Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309
反应条件
in dichloromethane
T=20°C; 1 h;
参考文献
Yue, Eddy W.; Gerdes, John M.; Mathis, Chester A.
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5451 - 5456
反应条件
in dichloromethane
T=20°C; 20 h;
参考文献
Joshua, Alummoottil V.; Sharma, Sanjay K.; Abrams, Douglas N.
Synthetic Communications, 2008 , vol. 38, # 3 p. 434 - 440
