(R)-2-氨基-3-羟基-3-甲基丁酸合成路线 （共 18 条）
反应条件
DOWEX 50 W x 8 cation exchange resin in hydrogenchloride; acetic acid T=100°C;
参考文献
Fitzi, Robert; Seebach, Dieter
Tetrahedron, 1988 , vol. 44, # 17 p. 5277 - 5292
反应条件
1: 87 percent / Cs2CO3 / dimethylformamide 2: 86 percent / AD-mix-β / Sharpless AD reaction 3: SOCl2 / CH2Cl2 4: NaIO4, RuCl3 / H2O 5: 1.) NaN3, 2.) H+ / 1.) Me2CO, H2O 6: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
1: 86 percent / AD-mix-β / Sharpless AD reaction 2: SOCl2 / CH2Cl2 3: NaIO4, RuCl3 / H2O 4: 1.) NaN3, 2.) H+ / 1.) Me2CO, H2O 5: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
1: SOCl2 / CH2Cl2 2: NaIO4, RuCl3 / H2O 3: 1.) NaN3, 2.) H+ / 1.) Me2CO, H2O 4: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
1: NaIO4, RuCl3 / H2O 2: 1.) NaN3, 2.) H+ / 1.) Me2CO, H2O 3: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
hydrogenchloride Ambient temperature;
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Schoellkopf, Ulrich; Groth, Ulrich; Gull, Martin-Reinhold; Nozulak, Joachim
Liebigs Annalen der Chemie, 1983 , # 7 p. 1133 - 1151
反应条件
hydrogen; palladium on activated charcoal Yield given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
1: 1.) NaN3, 2.) H+ / 1.) Me2CO, H2O 2: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2582 - 2583
反应条件
methyloxirane in ethanol 0.166667 h; Heating; Yield given;
参考文献
Synthesis, , # 10 p. 868 - 870
